Morphometric Analysis of Left & Right Tonsils in Adult Symptomatic Type 1 Chiari Patients and Healthy Controls

Historically, CMI has been radiographically defined by cerebellar tonsillar descent below the foramen magnum (FM) more than 5 mm (2). This measurement is typically made with a single sagittal plane T1-or T2-weighted MR image. Studies have obtained additional morphometric measurements to help diagnose CMI, and establish normal values (3,4). These studies were somewhat These studies were somewhat successful in differentiating CMI patients from healthy subjects. However, results from these studies have shown that the standard TD measurement does not necessarily correlate with neurological symptom severity as patients with CMI-like symptoms have been found with a TD of less than 5 mm position below the FM (6,7). Also, a variety of morphometric measurements have been found insufficient to differentiate disease states related to CMI such as syringobulbia (8). Past studies have reported that the TD measurement is not a good measure for diagnosis of CMI, yet it is still being used today (7). The primary goal for this study is to provide a better method for diagnosing CMI. One aspect that has not been analyzed in previous work is morphometric measurement of the left and right tonsil with using a constant reference point in the mid-sagittal plane. We hypothesize, using the proposed methodology, that the cerebellar tonsil descent relative to the FM will be lower based solely on a mid-sagittal slice compared to the 7 clinical operators measurements

The use of implicit evidence for relevance feedback in web retrieval

In this paper we report on the application of two contrasting types of relevance feedback for web retrieval. We compare two systems; one using explicit relevance feedback (where searchers explicitly have to mark documents relevant) and one using implicit relevance feedback (where the system endeavours to estimate relevance by mining the searcher's interaction). The feedback is used to update the display according to the user's interaction. Our research focuses on the degree to which implicit evidence of document relevance can be substituted for explicit evidence. We examine the two variations in terms of both user opinion and search effectiveness

Realising context-sensitive mobile messaging

Mobile technologies aim to assist people as they move from place to place going about their daily work and social routines. Established and very popular mobile technologies include short-text messages and multimedia messages with newer growing technologies including Bluetooth mobile data transfer protocols and mobile web access.Here we present new work which combines all of the above technologies to fulfil some of the predictions for future context aware messaging. We present a context sensitive mobile messaging system which derives context in the form of physical locations through location sensing and the co-location of people through Bluetooth familiarity

eBay users form stable groups of common interest

Market segmentation of an online auction site is studied by analyzing the users' bidding behavior. The distribution of user activity is investigated and a network of bidders connected by common interest in individual articles is constructed. The network's cluster structure corresponds to the main user groups according to common interest, exhibiting hierarchy and overlap. Key feature of the analysis is its independence of any similarity measure between the articles offered on eBay, as such a measure would only introduce bias in the analysis. Results are compared to null models based on random networks and clusters are validated and interpreted using the taxonomic classifications of eBay categories. We find clear-cut and coherent interest profiles for the bidders in each cluster. The interest profiles of bidder groups are compared to the classification of articles actually bought by these users during the time span 6-9 months after the initial grouping. The interest profiles discovered remain stable, indicating typical interest profiles in society. Our results show how network theory can be applied successfully to problems of market segmentation and sociological milieu studies with sparse, high dimensional data.Comment: Major revision of the manuscript. Methodological improvements and inclusion of analysis of temporal development of user interests. 19 pages, 12 figures, 5 table

The future of enterprise groupware applications

This paper provides a review of groupware technology and products. The purpose of this review is to investigate the appropriateness of current groupware technology as the basis for future enterprise systems and evaluate its role in realising, the currently emerging, Virtual Enterprise model for business organisation. It also identifies in which way current technological phenomena will transform groupware technology and will drive the development of the enterprise systems of the future

A phase 3, multi-center, multinational, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of levofloxacin inhalation solution (APT-1026) in stable cystic fibrosis patients

Rationale For patients with cystic fibrosis (CF), the use of inhaled antibiotics has become standard of care to suppress chronic Pseudomonas airways infection. There are limited antibiotic options formulated and approved for inhaled use and antibiotic efficacies attenuate over time, making additional inhaled antibiotic classes desirable. APT-1026 (levofloxacin inhalation solution, LIS) is a fluoroquinolone in development for management of chronic P. aeruginosa airways infection in patients with CF. Objectives To compare the safety and efficacy of a 28-day course of treatment with LIS 240 mg or placebo BID in persons ≥ 12 years old with CF and chronic P. aeruginosa infection. Methods A multinational, randomized (2:1), double-blinded study of LIS and placebo over 28 days in CF patients ≥ 12 years with chronic P. aeruginosa infection. Time to exacerbation was the primary endpoint. FEV1 (% predicted) and patient-reported quality of life were among secondary endpoints. Main results Baseline demographics for 330 subjects (LIS = 220) were similar although significantly more patients randomized to LIS had experienced multiple exacerbations in the year prior to study entry. There was no statistically significant difference in protocol-defined pulmonary exacerbations between treatment arms. Relative change in FEV1% predicted from baseline was significantly greater for patients randomized to LIS compared to those randomized to placebo (mean difference 1.31%, p = 0.01 [95% CI 0.27, 2.34%]). LIS was well-tolerated, with dysguesia the most frequent adverse event. Conclusions LIS did not demonstrate a difference in time to next exacerbation when compared to placebo. Reasons for this result are discussed but may be due to an imbalance in the frequency of prior pulmonary exacerbations between the two groups. An improvement in FEV1 (% predicted) at 28 days was observed and LIS was well tolerated. LIS is safe and has a potential role in the management of CF patients with chronic P. aeruginosa

Recipe Recommendation: Accuracy and Reasoning

Abstract. Food and diet are complex domains for recommender tech-nology but the need for systems which assist users in embarking on and engaging with healthy living programs has never been more real. With the obesity epidemic reaching new levels each day many practitioners are looking to ICT for novel and effective ways to engage and sustain engage-ment with online solutions. Here we report on a large scale analysis of real user ratings on a large set of recipes in order to judge the applicability and practicality of each. We use traditional content based, collaborative filtering and machine learning algorithms and discuss the trends in the data which reflect user reasoning and decision making strategies

Empirical analysis of web-based user-object bipartite networks

Understanding the structure and evolution of web-based user-object networks is a significant task since they play a crucial role in e-commerce nowadays. This Letter reports the empirical analysis on two large-scale web sites, audioscrobbler.com and del.icio.us, where users are connected with music groups and bookmarks, respectively. The degree distributions and degree-degree correlations for both users and objects are reported. We propose a new index, named collaborative clustering coefficient, to quantify the clustering behavior based on the collaborative selection. Accordingly, the clustering properties and clustering-degree correlations are investigated. We report some novel phenomena well characterizing the selection mechanism of web users and outline the relevance of these phenomena to the information recommendation problem.Comment: 6 pages, 7 figures and 1 tabl

A phase 3, open-label, randomized trial to evaluate the safety and efficacy of levofloxacin inhalation solution (APT-1026) versus tobramycin inhalation solution in stable cystic fibrosis patients

Background: Inhaled antibiotics are standard of care for persons with cystic fibrosis (CF) and chronic Pseudomonas aeruginosa airway infection. APT-1026 (levofloxacin inhalation solution, LIS) is fluoroquinolone in development. We compared the safety and efficacy of LIS to tobramycin inhalation solution (TIS) in persons ≥12 years old with CF and chronic P. aeruginosa infection. Methods: This multinational, randomized (2:1), non-inferiority study compared LIS and TIS over three 28-day on/off cycles. Day 28 FEV1 % predicted change was the primary endpoint. Time to exacerbation and patient-reported quality of life superiority were among secondary endpoints. Results: Baseline demographics for 282 subjects were comparable. Non-inferiority was demonstrated (1.86% predicted mean FEV1 difference [95% CI −0.66 to 4.39%]). LIS was well-tolerated, with dysguesia (taste distortion) the most frequent adverse event. Conclusions: LIS is a safe and effective therapy for the management of CF patients with chronic P. aeruginosa